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TY - JOURT1 - Histologic dating of the endometrium T2 - Advances in Anatomic Pathology AU - Fadare, Oluwole AU - Zheng, Wenxin PY - 2005/3Y1 - 2005/3N2 - The continued use of the endometrial biopsy for the diagnosis of luteal phase defects (LPDs) and in the general evaluation of the infertile couple is based largely on tradition, the absence of a clearly superior diagnostic modality, the absence of studies that have either validated or repudiated its efficacy with certainty, its ability to assess the endometrial response irrespective of endogenous progesterone levels, its ability to monitor the endometrial response to hormonal therapy in fertility treatments, and, finally, its ability to exclude other intrinsic endometrial anomalies that may be detrimental to the implantation of the conceptus, such as chronic endometritis or neoplasia.

AB - The continued use of the endometrial biopsy for the diagnosis of luteal phase defects (LPDs) and in the general evaluation of the infertile couple is based largely on tradition, the absence of a clearly superior diagnostic modality, the absence of studies that have either validated or repudiated its efficacy with certainty, its ability to assess the endometrial response irrespective of endogenous progesterone levels, its ability to monitor the endometrial response to hormonal therapy in fertility treatments, and, finally, its ability to exclude other intrinsic endometrial anomalies that may be detrimental to the implantation of the conceptus, such as chronic endometritis or neoplasia.

Neuroendocrine regulation of the corpus luteum in the human.

Basal body temperature graph and the luteal phase defect. The diagnosis and therapy of luteal phase deficiency. Monophasic basal body temperature in ovulatory menstrual cycles. Both midluteal serum progesterone levels and late luteal endometrial histology should be assessed in all infertile women. Corpus luteum dysfunction: serum progesterone levels in diagnosis and assessment of therapy for recurrent and threatened abortion. Regulation of luteal function by luteinizing hormone and prolactin at different times of the luteal phase.